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KMID : 1130620110070040231
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Journal of Clinical Neurology
2011 Volume.7 No. 4 p.231 ~ p.232
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A Patient with Genetically Confirmed Myoclonus-Dystonia Responded to Anticholinergic Treatment and Improved Spontaneously
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Lee Jae-Hyeok
Lyoo Chul-Hyoung
Lee Myung-Sik
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Abstract
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Background: The various medical treatments applied to myoclonus-dystonia patients with a mutation of the ε-sarcoglycan gene (SGCE) have not been beneficial in most cases. Most patients experience progressive deterioration or static clinical courses, with only rare cases of spontaneous remission.
Case Report: A 19-year-old girl presented with a 14-year history of myoclonus and dystonia that severely affected her left arm, neck, and trunk. Genetic studies showed a mutation in SGCE [deletion in exon 6 (c.771_772delAT, Cys258X)]. Both myoclonus and dystonia responded to anticholinergic treatment for 7 years and improved spontaneously.
Conclusions: The possibility of spontaneous improvement should be kept in mind when considering the therapeutic strategy in myoclonus-dystonia patients, especially when contemplating deep-brain stimulation.
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KEYWORD
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myoclonus, dystonia, anticholinergics, spontaneous remission
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